Gemcitabine and irinotecan as first-line therapy for carcinoma of unknown primary: results of a multicenter phase II trial.

Metastatic carcinoma of unknown primary (CUP) has a very poor prognosis, and no standard first-line therapy currently exists.Here, we report the results of a phase II study utilizing a combination of gemcitabine and irinotecan as first-line therapy.Treatment was with gemcitabine 1000 mg/m(2) and irinotecan 75 mg/m(2) weekly times four on a six week

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A Hybrid Virtual Network Function Placement Strategy for Maximizing the Profit of Network Service Deployment Over Time-Varying Workloads

The emergence of network function virtualization (NFV) has revolutionized the infrastructure and service management of network architecture.It allows network operators to reduce costs and improve the agility of network service deployment.But finding the best VNF placement is a well-known NP-complete problem.Hence, many previous ABSOLUE KERATINE MAS

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Holiday as element of cultural memory of migration community

Identifying the difference between social and political holidays the article considers the holiday as the integral element of cultural memory.The author specifies that political privatization of a holiday is shown in creation of the BREAST/NIPPLE new calendar of the memorable events promoting creation and fixing ABSOLUE KERATINE MASK THICK the coll

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